You have reached the web-site of the Frueh laboratory. You are welcome. Our laboratory has a dual purpose that gives rise to synergistic advances in multiple fields. We seek to unravel the molecular mechanisms of nonribosomal peptide synthetase (NRPS) domain communication, and we develop nuclear magnetic resonance (NMR) methods that facilitate studies of such challenging and dynamic proteins. Our investigations also include biochemical assays, and may be supplemented with biophysical methods such as isothermal titration calorimetry or fluorescence anisotropy. We believe that science is motivated by problem solving, and each lab member is set to solve a particular riddle that encompasses all aspects of our research. That is, a project will include wet-lab work (e.g. cloning, biochemistry), data collection and analysis (advanced NMR methods, supporting techniques), and dry-lab work (software and scripting/coding). In the end, we simultaneously advance our understanding in NRPS synthesis, push the frontiers of NMR, and help understand the role of protein dynamics in biochemistry. Enjoy your visit.